Creosote is said to have many uses. Indigenous people have used it for for the treatment of at least fourteen afflictions and diseases: colds, chest infections or lung congestion, intestinal discomfort, stomach cramps associated with delayed menstruation, consumption, cancer, nausea, wounds, poisons, swollen limbs due to poor circulation, dandruff, body odor, distemper, and postnasal drip .
Creosote is also said to have antimicrobial properties, making it a useful first aid antiseptic. It is also said to be beneficial in the treatment of allergies, autoimmune diseases, and Premenstrual Syndrome.
Creosote leaves may serve as an analgesic, anti-diarrheal, diuretic, and emetic. Creosote can be used on the skin as a tincture or salve Native Indians used creosote for ritual purposes and to cleanse the air.